Author Archives: Claudia Foubert

Final Podcast – Siesta Fiesta

Bibliography

“Depression.” NIMH RSS. Web. 26 Apr. 2016. <https://www.nimh.nih.gov/health/topics/depression/index.shtml>.

“Drugs and the Brain.” National Institute of Drug Abuse. National Institute of Health, July 2014. Web. 26 Apr. 2016. <https://www.drugabuse.gov/publications/drugs-brains-behavior-science-addiction/drugs-brain>.

Harrison, Yvonne, and James A. Horne. “The Impact of Sleep Deprivation on Decision Making: A Review.” APA PsycNET. American Psychological Association, Sept. 2000. Web. 26 Apr. 2016. <http://psycnet.apa.org/journals/xap/6/3/236/>.

Hirshkowitz, Max, Kaitlyn Whiton, Steven M. Albert, and Cathy Alessi. “National Sleep Foundation’s Sleep Time Duration Recommendations: Methodology and Results Summary.” Sleep Health Journal of the National Sleep Foundation 1.1 (2015): 40-43. Web. <http://www.sleephealthjournal.org/article/S2352-7218(15)00015-7/fulltext>.

Insel, Thomas. “Director’s Blog: Antidepressants: A Complicated Picture.” National Institute of Mental Health. National Institute of Health, 6 Dec. 2011. Web. 26 Apr. 2016. <http://www.nimh.nih.gov/about/director/2011/antidepressants-a-complicated-picture.shtml>.

Nugent, Colleen N., and Lindsey I. Black. “Sleep Duration, Quality of Sleep, and Use of Sleep Medication, by Sex and Family Type, 2013–2014.” Centers for Disease Control and Prevention (2016): n. pag. National Center for Health Statistics. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, Jan. 2016. Web. 25 Apr. 2016. <http://www.cdc.gov/nchs/data/databriefs/db230.pdf>.

Pietrangelo, Ann. “Effects of Sleep Deprivation on the Body.” Healthline. Healthline, 19 Aug. 2014. Web. 25 Apr. 2016. <http://www.healthline.com/health/sleep-deprivation/effects-on-body>.

“Sleep and Disease Risk.” Healthy Sleep. Harvard Medical School, 18 Dec. 2007. Web. 26 Apr. 2016. <http://healthysleep.med.harvard.edu/healthy/matters/consequences/sleep-and-disease-risk>.

“Sleep On It.” NIH News in Health RSS. Ed. Vickie Contie and Harrison Wein. National Institute of Health, Apr. 2013. Web. 26 Apr. 2016. <https://newsinhealth.nih.gov/issue/apr2013/feature2>.

Williamson, A. M., and Anne-Marie Feyer. “Moderate Sleep Deprivation Produces Impairments in Cognitive and Motor Performance Equivalent to Legally Prescribed Levels of Alcohol Intoxication.”Occupational and Environmental Medicine. BMJ Publishing Group Ltd., 15 June 2000. Web. 25 Apr. 2016. <http://oem.bmj.com/content/57/10/649.full>.

Voderholzer, Ulrich. “Sleep Deprivation and Antidepressant Treatment.” Dialogues in Clinical Neuroscience 5.4 (2003): 366–369. Print.

United Therapeutics CV

Global Drug Safety Internship Inquiry

12 March 2016

Amanda Saunders
Pharmacovigilance Physician
United Therapeutics
55 T.W. Alexander Drive
P.O. Box 14186
Research Triangle Park, NC 27709

 

Dear Dr. Saunders:

I am writing to you in regards to an open summer associate position in your global drug safety department and want to convey my excitement at the opportunity of joining United Therapeutics. As an undergraduate at the University of North Carolina at Chapel Hill majoring in Psychology with a minor in Neuroscience on the pre-med track, I am very eager to broaden my knowledge of the medical disciplines and explore the field of healthcare. I found your job listing to be most closely related to my pharmaceutical interests and offered the best introductory experience to the professional industry. Prior experience in art and research has fortified my skills necessary to succeed in such a collaborative work environment as well as commit to responsibilities with great focus.

While working in Dr. Sara Algoe’s emotional and social relations research lab, I had to adhere to strict standards when coding participant behavior. After coding hundreds of videos, I have gained a better understanding of the importance of patience and attention to detail when analyzing data. These precise evaluation skills will prove especially advantageous when assisting in acute review of human safety and global distribution operating procedures.

My 8-year background in the performing arts also contributes to my affinity for teamwork and creative outlook. In addition, I am able to employ my fluency in several languages to better communicate with others who more clearly express themselves in a language other than English. Such international communication is critical in reviewing complaints and complimentary to the “global” aspect of the drug safety department. Raised in a multicultural household, I have also learned to approach problems with an open mind and consider various perspectives. While offering a creative mindset to the global drug safety team, working at United Therapeutics would grant me a new perspective on medical professions and their global applications.

I want to ensure you that I am self-motivated with a genuine passion for medicine and believe this opportunity to assist with drug safety review will enhance my academic growth in addition to being an impactful contributor to your team.

Sincerely,

Claudia Foubert
Undergraduate at the University of North Carolina at Chapel Hill
515 Paul Hardin Drive, Rm# 332
Chapel Hill, NC 27514

Unither Internship Profile

United Therapeutics is a biotechnological company engaged in the development and commercialization of therapeutic products for patients with chronic and life-threatening cardiovascular, cancerous, and infectious diseases. In the summer, Unither provides three levels of summer employment for students at the college and graduate school level – Advanced Degree Interns, Interns, and Seasonal Support Associates. Depending on the completion of the job description for the potential internship I may receive, I will either apply to work as an Intern or Seasonal Support Associate.

Interns are college students that will work on a project related to their major or department. They will assist their team with specific tasks related to their department, enriching their education on how their department supports the overall institution. By the end of their 90-day employment, interns are expected to have worked on and completed a presentable project. A full internship will have an hourly salary rate of $15.00. However, it is unlikely that I will receive this level of summer employment because most interns are rising junior and senior undergraduates. Therefore, I expect to work as a Seasonal Support Associate, offering administrative support to an assigned team. Tasks will include, but are not limited to, filing, scanning, making binders, data entry, copying documents, etc. Meanwhile, associates will have exposure to the pharmaceutical industry and may work specifically in a desired field. The position that I will be applying for will have some application to the field of psychology and neuroscience.

Similar to Interns, Seasonal Support Associates will commit to 90 calendar days of employment at an hourly pay of $11.00. Nonetheless, Unither is flexible and offers breaks to its employees, as needed. Both interns and associates will begin working on either May 30th or June 13th, depending on their particular job. Orientation and any necessary training will occur around these dates.

Credentials and academic requirements are less robust for associates than for interns. Students must be 18 years of age with the intention of pursuing either a Masters or PhD. Other related academia is not required but preferred in the application process. Notwithstanding, a cover letter and CV are necessary along with a letter of recommendation prepared upon request. An interview process is also expected to follow any promising application.

Overall, the option of working at Unither this summer will prove beneficial in expanding my work experience in a professional, medical business. In terms of accessibility, the company location is a mere 20-minute driving distance from my house. I will have easy access to transportation to and from the Research Triangle everyday since my mother will also be traveling to Unither for work. In addition, I have previously visited the company and find the work environment to be very clean, safe, and comfortable. An internship at Unither will be most practical and of minimal cost. In contrast, working as an associate will not directly relate to my field of interest. Until the job description is developed, I will not know exactly what I will be applying for. Another concern is that both starting dates are during the final weeks of UNC summer school in which I plan to attend. If flexibility is permitted and I am able to commence three days after standard orientation, then I will have no other time conflicts with the internship. Unfortunately, by accepting the internship, I will not have much free time to travel in the summer.

I still have yet to know of the application deadline as well as the weekly hours of work, end date of employment, and specific job description.

Claudia Foubert

A Resounding Approach To A Sounder Health

Photo by Fraser 70D on August 19, 2013

Claudia Foubert

Music has become a prevalent, almost essential, part of our lives. We crank up the volume and reflect in this sound mirror that reveals our inner selves, lending a voice to our unspeakable feelings and transporting our bodies to distant memories. The impressive role music plays on our emotional and social state has attracted much attention from psychologists and even influenced a new wave of modern therapy. But while many of us are aware of this musical revelation, a more intriguing facet has gone largely unnoticed: the most fundamental unit of music – sound.

Unlike music, sound constantly surrounds us. The beeping of a crosswalk, the whir of a fan, and the tapping of a keyboard, although unconsciously processed, have profound effects on our whole selves. Humans are bounding bodies of energy. We are entities consisting of cells that simultaneously vibrate at a rate of eight cycles per second, in astonishing congruence with the earth. Remarkably, sounds resonate with our cores just as well.

Audible or inaudible, they produce frequencies that align with the body’s core vibrations and unite body with sound. Like two dance partners, the perfect combination of frequency and being results in a harmonious ballad that feels effortless in each sway. In contrast, an incompatible vibration can disrupt our rhythm and have undesirable effects on our mood and comfort. If we could channel these “good vibrations” to tune our bodies, the benefits of a safe and natural practice would be worth something the Beach Boys would sing about! Fortunately, such a therapy exists.

Vibroacoustic sound therapy (VAST) is an alternative medical method that uses specific frequencies to heal both mind and muscle. Although this treatment has not garnered much attention, such a practice has been used far longer than one may expect. Dating as far back as 3600 BC, ancient peoples manipulated wall structure to capture sound and enhance vibrations that stimulate brain activity. Substituting chemical drugs with natural energy, this relaxation technique had a profound effect on early civilizations, so why not ours?

In an age where a copious assortment of pills stock grocery shelves, people have begun to rely on the unknown and not trust in nature’s given healers. To believe that something nontangible, such as vibrations, could touch us in such a physical way may seem incredible but is really only the beauty of nature.

The oracle chamber of the Maltan Ħal-Saflieni Hypogeum. Ancient architects employed concave walls, niches, and cuts to control the movement of sound waves. Photo by Heritage Malta on January 21, 2009.

Modern medicine should focus on VAST and expand its use as an alternative, if not preferred, mental remedy. Though, where the mind goes, the body follows. Not only do vibrations elicit mental and emotional responses, but they also contain healing properties for physiological maladies. With psychological and physiological benefits, vibroacoustic sound therapy potentiates an impactful shift in current medical perspectives.

Placing hope in an evolving treatment, the school for the profound and multiple handicapped children (PLMD) sought to bring expression, awareness, and control to the fully dependent children who experienced various cognitive and physical disabilities. However, even with such a newly beneficial therapy, help seemed bleak. That is, until a boy with a particularly severe case cast hope.

M was in no way an obvious candidate for improvement. Suffering from cerebral palsy, epilepsy, uncontrollable spasms, as well as partial deafness and blindness, M disliked any form of interaction and would often isolate himself in his thoughts. Any chance he had to regain the essence of himself was soon put in the hands of sound therapy researchers. Treatments focused on vocal interaction through changes in pitch and volume as well as relaxation by low frequencies. Motor control was specifically targeted by the Soundbeam, an ultrasonic beam that produces a sound at any detected movement. In addition to intensive care, VAST offered M an ability he had not previously known – complete control.

A handicapped child uses Soundbeam to signal and increase awareness of his motor movements.

As a non-invasive therapy, VAST circumvents all fear of the unknown effects of a squishy, green pill and looming, radioactive machines and instead provides an aural and tactile explanation of sound medicine. Based on his own movements, M had the power to decide what sounds would be produced by the Soundbeam and when. Not only does this control promote mental involvement but it also challenges one to accept the healing process and willingly participate in prospect of positive results.

In the first year of sound therapy, M gained some conscious motor control and demonstrated finer, smoother movements. By his third year, M was increasingly aware of his surroundings, nearly able to sing along to certain music and often smiling. His apparent agitation would cease once therapy began as he sat upright, became mindful of his actions, and showed pleasure in self-expression.

What started out as a doubtful premise turned into an unimaginable success that no other practice could produce. VAST proved to have major effects on M and may be the needed solution for many others. Unlike other treatments, VAST emphasizes the importance of well-being, fusing both internal and external recovery. Nonetheless, a more physical application of vibrations does exist.

If vibrations can stimulate brain activity, then could such frequencies expand their influence on physical activity, or physical healing? M. Roelants, C. Delecluse, and S. Verschueren sought to explore this question in their experiment observing the unknown effects of vibrations on muscle deterioration. Their study specifically tested elderly women due to the participants’ age-related decrease in physical activity.

Employing whole-body-vibration (WBV) training, researchers had participants perform both static (immobile) and dynamic (joint-moving) exercises on a frequency-emitting platform. These frequencies would, in turn, stimulate sensory receptors that activate reflexive muscle contractions, similar to those experienced during physical activity.

A platform emits whole body vibrations.

A platform emits whole body vibrations.

After twelve weeks of WBV therapy, a significant improvement was noted in the women’s isometric and dynamic strength, speed of movement in knee extension, and counter movement jump performance. When compared to the conventional resistance training group (RES) who performed more rigorous exercises on a normal gym floor, the WBV group did not show significant advantages in resulting muscular strength. Therefore, WBV therapy proves to be just as efficient as the traditional form of exercise training for the elderly. Subsequently, VAST is a safer, less demanding exercise tool that minimizes strain on the elderly’s physical abilities.

As vast as the benefits may seem, should vibrations reign supreme to the ubiquitous use of drugs?  Well, not necessarily…

Ultrasound serves as a median between vibration and drug. Using low frequencies, clinical ultrasound penetrates the permeability of the skin barrier and allows easy drug intake and diffusion. This needle-free technique known as sonophoresis occurs through induced cavitation (formation of an opening) and has unprecedented accuracy in its administration, targeting specific muscles and cells and minimizing invasive drug exposure. Such precision can be used in the destruction of cancer cells as well as lipoplasty, the restructuring of fat molecules. In addition, heat-inducing sound waves and enhanced protein synthesis can facilitate bone growth and tissue relaxation. Although now used in a variety of instances, medical ultrasound continues to be studied due to its diverse and unknown effects.

Ultrasonic waves change the permeability of the membrane and facilitate diffusion of drugs.

Ultrasonic waves change the permeability of the membrane and facilitate diffusion of drugs.

So, if you remain skeptical on the idea of vibrational healing and are stuck on conventional prescription medication, then ultrasound may be a perfect intermediate for you.

The intertwining psychological and physiological effects elucidate VAST as a promising practice that uses nature to balance nature. The power of vibrations is evermore significant as the world becomes busier, noisier, and smaller. Now is the time to listen and find the harmony within the crowd.

A Resounding Approach to a Sounder Health – Query Letter

Claudia Foubert
919 Paul Hardin Dr.
Chapel Hill, NC 27514
claudiaf@live.unc.edu
February 4, 2016

Dear Mrs. Boyd,

I want to inform you and your greater audience about the importance and benefits of the unfamiliar medical approach of vibroacoustic sound therapy. My name is Claudia Foubert and I am a Psychology and Neuroscience major in the undergraduate level at the University of North Carolina at Chapel Hill. I am pleased to introduce you to my most recent article, A Resounding Approach to a Sounder Health, and believe that it is a perfect fit for Nature Medicine.

Music has become a prevalent, almost essential, part of our lives. We crank up the volume and reflect in this sound mirror that reveals our inner selves, lending a voice to our unspeakable feelings and transporting our bodies to distant memories. The impressive role music plays on our emotional and social state has attracted much attention from psychologists and even influenced a new wave of modern therapy. But while many of us are aware of this musical revelation, a more intriguing facet has gone largely unnoticed: the most fundamental unit of music – sound.

Unlike music, sound constantly surrounds us. The beeping of a crosswalk, the whir of a fan, and the tapping of a keyboard, although unconsciously processed, have profound effects on our whole selves. Humans are bounding bodies of energy. We are entities consisting of cells that simultaneously vibrate at a rate of eight cycles per second, in astonishing congruence with the earth. Remarkably, sounds resonate with our cores just as well. Audible or inaudible, they produce frequencies that align with the body’s core vibrations and unite body with sound. Like two dance partners, the perfect combination of frequency and being results in a harmonious ballad that feels effortless in each sway. In contrast, an incompatible vibration can disrupt our rhythm and have undesirable effects on our mood and comfort. If we could channel these “good” vibrations to tune our bodies, the benefits of a safe and natural practice would be worth something the Beach Boys would sing about! Fortunately, such a therapy exists.

Vibroacoustic sound therapy (VAST) is an alternative medical method that uses specific frequencies to heal both mind and muscle. Although this treatment has not garnered much attention, such a practice has been used far longer than one may expect. Dating as far back as 3600 BC, ancient peoples manipulated wall structure to capture sound and enhance vibrations that stimulate brain activity. Substituting chemical drugs with natural energy, this relaxation technique had a profound effect on early civilizations, so why not ours? In an age where a copious assortment of pills stock grocery shelves, people have begun to rely on the unknown and not trust in nature’s given healers. To believe that something nontangible, such as vibrations, could touch us in such a physical way may seem incredible but is really only the beauty of nature. Modern medicine should focus on VAST and expand its use as an alternative, if not preferred, mental remedy. Though, where the mind goes, the body follows. Not only do vibrations elicit mental and emotional responses, but they also contain healing properties for physiological maladies. With psychological and physiological benefits, vibroacoustic sound therapy potentiates an impactful shift in current medical perspectives.

In the continuation of this article, I will address the implementation of VAST on both mental and physical treatments as well its efficiency and practicality in regard to prescription medication. A case study will follow a young boy with cognitive and physical disabilities who develops better motor control, external awareness, and increased optimism with the use of sound technologies. I will also explore studies explaining the use of vibrations in various medical treatments, such as tissue repair and muscle strengthening. As a result, ultrasound technology will be examined as an efficient means of growth and healing at the microscopic scale. The intertwining psychological and physiological effects elucidate VAST as a promising practice that uses nature to balance nature. The power of vibrations is evermore significant as the world becomes busier, noisier, and smaller. Now is the time to listen and find the harmony within the crowd.

Please consider this article for publication as I believe that the topic of vibroacoustics will intrigue a broad audience. Feel free to contact me with any question you might have.

Thank you for your time,
Claudia Foubert

Vibroacoustic Sound Therapy

Brewer, Jane F. “Hearing Sounds.” Complementary Therapies in Nursing and Midwifery 4.1 (1998): 7-12. Science Direct. 2016 Elsevier B.V., 1 June 2006. Web. 25 Jan. 2016.

Musical vibrations can synchronize physical responses and emotions between people, resolving social conflicts. Thus, the article explores how such physical and emotional change can be used in medical therapy. Several case studies are presented demonstrating the effects of sound waves – calmness, focus/alertness, relaxation – on students and patients. The human body is an energetic entity consisting of cells that vibrate at 8 cycles per second, in congruence with the earth. Music, audible or inaudible, can produce frequencies that align with the body’s core vibrations and create harmony and peace within. Music therapy specifically aims at reducing pain and anxiety, helping patients reach another state of consciousness by altering their perception of time and connecting both brain hemispheres. At higher frequencies, sound waves are translated into colors that, in turn, cause different emotions, aligning the senses. Nonetheless, every individual is different and must find a frequency that aligns with their body’s own tune and produces a matching color and emotion.

 

Mitragotri, Samir. “Healing Sound: The Use of Ultrasound in Drug Delivery and Other Therapeutic Applications.” Nature Reviews. Drug Discovery 4.3 (2005): 255-60. Nature. 2016 Macmillan Publishers Limited, 1 Mar. 2005. Web. 25 Jan. 2016.

The article discusses modern, therapeutic uses of clinical ultrasound. Ultrasound is able to target specific muscles and cells and relax tissues with heat-inducing sound waves. Such a process is also outlined to explain deep biological and chemical effects. Using different frequencies, medical ultrasound is combined with drugs in order to penetrate the permeability of the skin barrier and allow easy drug intake and diffusion. In addition, ultrasound facilitates healing in tissues, specifically bones, as a result of induced protein synthesis. Overall, ultrasound is now used in a variety of instances but needs to be further studied due to its diverse and unknown effects.

 

“Discovery of Ancient “Super-Acoustics” may have Modern Therapeutic Value.” PR Newswire. 9 Jul 2014. ProQuest. Web. 25 Jan. 2016

In Malta’s underground Hal Saflieni Hypogeum, scientists have discovered that the use of vibrations to stimulate human brain activity has long been used, dating as far as 3600-2400 BC. Once a temple for the dead, the Hypogeum also served as an acoustic chamber where the presence of double resonance frequencies led to hallucinations and deep meditation. The temple’s architecture portrays the knowledge of the ancient people since its use of concave walls, niches, and cuts greatly resembles modern designs structured to control sound waves.

 

Roelants, Machteld, Christophe Delecluse, and Sabine M. Verschueren. “Whole-Body-Vibration Training Increases Knee-Extension Strength and Speed of Movement in Older Women.” Journal of the American Geriatrics Society 52.6 (2004): 901-08. Web. 27 Jan. 2016.

Research was conducted to examine the long term effects of whole body vibration (WBV) on muscle strength in older women. After twelve weeks, women who had experienced WBV training improved significantly in isometric and dynamic strength, speed of movement in knee extension, and counter movement jump performance. Although the study continued for twenty-four weeks, the most significant improvements were most prevalent after twelve weeks of training. Standing on a platform, women would receive vibrations and frequencies that stimulated reflexive muscle contractions similar to those during physical activity. In the end, the research discusses the idea that unloaded (immobile) WBV training may serve as a safer therapy than resistance training for the elderly.

 

Ellis, Phil. “Improving Quality of Life and Well-Being for Children and the Elderly through Vibroacoustic Sound Therapy.” Lecture Notes in Computer Science Computers Helping People with Special Needs3118 (2004): 416-22. Web. 27 Jan. 2016.

In 1992, a research project sought to use Vibroacoustic Sound Therapy (VAST) to help handicapped children better control their motor movements and express themselves with the surrounding world. Several musical technologies were used for different physiological purposes, focusing on the use of sounds and vibrations to elicit communication, self-awareness, and self-control. One case study follows a young boy, M, who experienced many cognitive and physical disabilities but became happier and more relaxed with five years of VAST. Once having uncontrollable spasms and lacking response to external stimuli, M began to smile, have smoother muscle movements, focus, and communicate with his surroundings.

 

Autism On My Mind

The article discusses the early history of how autism was “discovered.” Many believed that people who portrayed signs of what is known today as autism, were idiots. Idiots was a medical term that meant someone was intellectually inferior and incapable of learning. Nonetheless, a doctor observed these socially incompetent people and believed that they were not dumb at all because they were able to perform tasks that showed intellectual ability, such as counting and multiplying. Following this realization, other doctors, including Howe, opened education facilities for people with autism.